Colitis associated with non-steroidal anti-inflammatory drugs.

Colitis caused by non-steroidal anti-inflammatory drugs.

Four cases of acute proctocolitis associated with non-steroidal anti-inflammatory drug therapy are presented. The drugs implicated were flufenamic acid, mefenamic acid, naproxen and ibuprofen. After resolution of symptoms and signs of proctocolitis three of the four patients were subsequently rechallenged with the implicated drug: in each there was a rapid relapse.

Non-steroidal anti-inflammatory drugs.

Renal impairment associated with non-steroidal anti-inflammatory drugs

SIR, The study by Unsworth et al' would appear to have methodological deficiencies which limit both its conclusions and its applicability to rheumatic patients taking nonsteroidal anti-inflammatory drugs (NSAIDs). These include the reason for choosing to discontinue the medication in a particular individual; the lack of information about the reason for admission of the patients, and particularl...

Renal impairment associated with non-steroidal anti-inflammatory drugs

SIR, The study by Unsworth et al' would appear to have methodological deficiencies which limit both its conclusions and its applicability to rheumatic patients taking nonsteroidal anti-inflammatory drugs (NSAIDs). These include the reason for choosing to discontinue the medication in a particular individual; the lack of information about the reason for admission of the patients, and particularl...

Renal impairment associated with non-steroidal anti-inflammatory drugs.

We have compared the renal function on admission and discharge of 22 patients routinely admitted to our rheumatology ward. None had previously diagnosed renal failure. Of 11 patients in whom we stopped long term non-steroidal anti-inflammatory drug (NSAID) therapy, all showed a rise in creatinine clearance (Ccr) after three to 28 days. In contrast, a control group comprising 11 similar patients...